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To facilitate the clinical use of a mini-ridge filter, we performed a planning study for the feasibility of a mini-ridge filter A mini-ridge filter is often used to widen the Bragg peak in the longitudinal direction at low energies but not high energies.

To facilitate the clinical use of a mini-ridge filter, we performed a planning study for the feasibility of a mini-ridge filter as an integral part of the synchrotron nozzle (IMRF).

Dose models with and without IMRF were commissioned in a commercial Treatment planning system (TPS).

Dosimetric characteristics in a homogenous water phantom were compared between plans with and without IMRF for a fixed spread-out Bragg peak width of 4 cm with distal ranges varying from 8 to 30 g/cm.

Mesenchymal markers on the surface of EMT CTCs were found to be associated with metastasis and could serve as potential biomarkers for metastasis.

Altogether, these studies indicate that EMT is orchestrated by a complicated network, involving regulators of different signaling pathways.

Full article A mini-ridge filter is often used to widen the Bragg peak in the longitudinal direction at low energies but not high energies.Downregulation of these mi RNAs is associated with distant metastasis and advanced stage tumors.Furthermore, the role of EMT in circulating tumor cells (CTCs) is also discussed.The c-Met pathway has been shown to regulate many cellular processes such as cell proliferation, invasion, and angiogenesis.The c-Met pathway is involved in cross-talk, activation, and perpetuation of other signaling pathways, curbing the cogency of a blockade molecule on a single pathway.