His catchphrase "Giggity" has been used many times in popular culture since the beginning of the show in 1999, such as in a in Progressive automobile insurance advertisement and the January 4, 2011 episode of Around the Horn.Years ago, Quagmire used to go out with Cheryl Tiegs, whom he loved.He has a sister who gets beaten by her boyfriend and a deaf brother.He also has a son in Madrid, Spain who greatly resembles Quagmire, but with a snappy mustache and a ponytail, as seen in "Peter's Got Woods" despite claiming never to have had sex with a Spanish woman.
He was also briefly married to a maniac named Joan. Quagmire is currently a widower, although this is no problem for him, as he can now get it on with more girls, without having to worry about cheating. Tragically, when Quagmire went to Vermont to buy a present for James, Peter, Cleveland, and Brian, go over to Quagmire's to shave James as a prank, which backfired when Peter accidentally stabs James.Quagmire is often seen saying "all right" while rocking his head back and forwards in an amusing way.Quagmire has been shown to be extremely affectionate towards animals, specifically a cat he named James in "420".The conflict between him and Brian continues in "Quagmire's Dad" when furious Quagmire attacking Brian for dating his sex-changed father, despite the fact that Brian wasn't aware of this until Stewie told him just before Quagmire confronted.Brian gets the final word, however, when he says to Quagmire, "I fucked your dad." Since then, the running gag has been whenever the two interact, Quagmire has been upset to Brian, despite Brian's attempts to be polite.